The effects of agomelatine in cisplatin-induced toxicity on the kidney and liver tissues: In vivo study

Nephrotoxicity and hepatotoxicity are frequently seen adverse effects during cisplatin chemotherapy. In this study, we investigated the of agomelatine on cisplatin-induced toxicity in kidney liver. Animals were administered with a single dose (7 mg/kg, i.p.) treated (20 40 p.o) for seven days. Renal hepatic functions evaluated by measuring concentrations creatinine, BUN, AST ALT serum. Oxidative stress protein peroxidation assessed SOD, CAT, GSH AOPP levels both tissues. Serum PON-1 also evaluated. Histopathological analysis was performed to determined structural changes Agomelatine mg/kg) treatment approximately halved cisplatin-related increase serum levels. significantly prevented excessive decrease tissues protected integrity against cisplatin-insult. Although (40 showed parallel results 20 mg/kg biochemically, it failed show same liver tissue analyses. liver, care should be taken higher doses possible hepatotoxicity.